The Lethal Drug Trial That Turned Men Into Elephants
A video on YouTube. In Documentaries, a Krater category.
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A documentary dramatization following the 2006 TGN1412 clinical drug trial in London where six healthy male volunteers suffered multiple organ failure due to an unprecedented cytokine storm.
From the video
Answers: What happened during the 2006 TGN1412 drug trial disaster at Northwick Park Hospital?
- clinical drug trials
- monoclonal antibodies
- Phase 1 human trials
- TGN1412 drug trial
- cytokine release syndrome
- Northwick Park Hospital
What it concludes
- The TGN1412 drug trial disaster occurred because the drug was administered ten times quicker into the human bloodstream than it had been in monkey studies.
- The independent report concluded that the adverse effects were the result of an unpredictable biological action of the drug in humans.
- The MHRA report and subsequent investigations recommended that high-risk trials should take place within a hospital with access to intensive care.
- In 2013, TGN1412 successfully passed Phase One human trials in Russia under the name TAB08 using 0.1% of the antibody dose and infusing it 40 times more slowly.
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